Development of biopolymeric scaffolds for bone regeneration
Author(s):
Raja Rajeshwari S P, Angel Jemima E
Keywords:
Tissue engineering, PVA, scaffold, bone regeneration, biopolymers, cellulose.
Abstract
Biomaterial scaffolds are used in bone tissue engineering to provide support repair and regeneration of bone defects. To develop a biopolymeric scaffolds for the treatment of bone regeneration using cellulose from paddy straw. To synthesize bio scaffold, cellulose was extracted from paddy straw. There are two bio scaffolds were prepared using cellulose material and PVA. The scaffold was analysed for their swelling ratio, hemocompatibility, cytotoxicity and antimicrobial analysis were carried out to analyze their efficiency in vitro. Our results showed that, the biosynthesized 1 % and 10 % PS scaffolds were able to swell and found to be nontoxic to Vero cells. The IC50 value of both 1 % and 10 % PS scaffolds were found to be 377.7 μg/ml and 436.2 μg/ml respectively. The hemocompatibility results also confirmed that the PS scaffolds were hemocompatible upto the concentration of 1000 μg/ml. The antimicrobial results of both 1 % and 10 % PS scaffolds were shown to inhibit the S. pyogenes (17 mm), Aspergillus niger (8 mm and 16 mm) microbial growth at the concentration of 500 μg/ml. Taken together, these results confirm that, PS bioscaffolds were found to be highly hemo and cytocompatible and can be used for the treatment of bone regeneration.
Article Details
Unique Paper ID: 152818

Publication Volume & Issue: Volume 8, Issue 4

Page(s): 520 - 527
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