DRUG REPURPOSING IN ANTIVIRAL RESEARCH: A REVIEW
Author(s):
VAISHNAVI R. MAHAJAN, SHYAMLILA B. BAVAGE, NANDKISHOR B. BAVAGE
Keywords:
Drug repurposing, antiviral, drug discovery, viral infection.
Abstract
Drug discovery and development are long, huge costly and time consuming processes. On an average it takes at least 10 years and cost 2.6 billion USD for successful drug discovery and approval for clinical use. Drug repurposing is a promising, fast and cost-effective method that can overcome traditional de novo drug discovery and development challenges of targeting various diseases. Drug repurposing is a process of identifying new therapeutic use for old and existing drugs. It is highly efficient strategy in the developing drug molecules with new pharmacological and therapeutic indications. In recent years, many pharmaceutical companies are developing new drugs with the discovery of novel biological targets by applying the drug repositioning strategy in drug discovery and the development processes. This strategy is an effective, time saving, low-cost and minimum risk of failure. It increases the therapeutic value of a drug and hence it increases the success rate. Thus, drug repositioning is an efficacious, successful and alternative approach to traditional drug discovery process. The repurposing approach has given many promising drug candidates for various viral infectious diseases like Ebola, Influenza, ZIKA, dengue, HIV infections and various other viral infectious diseases. The emergence of resistance to existing antiviral drugs and re-emerging viral infections are the biggest challenges in antiviral drug discovery process. The drug repurposing approach is an assuring strategy in finding new antiviral agents within a short period of time to overcome the challenges in antiviral therapy. In this review, we describe the most promising results of the drug repurposing approach in the treatment of various viral infectious diseases.
Article Details
Unique Paper ID: 153075

Publication Volume & Issue: Volume 8, Issue 5

Page(s): 387 - 392
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