Evaluation of antidiabetic potential of Maytenus emarginata leaves in alloxan induced diabetic rats
Author(s):
KAMALA CHANDAK, Milind Umekar, Shalakha Dabhekar
Keywords:
Maytenus emarginata, phytochemical screening, antidiabetic activity, Alloxan.
Abstract
Maytenus emarginata (Wild.) Ding Hou (Celastraceae) fresh leaves juice is traditionally used by diabetic patients in Vidarbha region. The present study was aimed to investigate the anti-diabetic potential of aqueous extract of Maytenus emarginata leaves in alloxan induced diabetic rats at 50, 100 & 200 mg/kg doses. The blood glucose level of experimental animals was determined at 0, 1, 3 and 5 hrs after treatment with aqueous extract using glucomate. Metformin HCl (120 mg/kg) was used as a reference standard. The preliminary phytochemical screening of the aqueous extract of leaves showed presence of carbohydrates, flavonoids, alkaloids, tannins etc. All the three doses of aqueous extract (50, 100 and 200 mg/kg) significantly reduced the blood glucose level at 5 hours of treatment in diabetic rats. The percentage reduction in blood glucose level was found to be 35.6, 53.65 and 61.39 respectively and it was dose dependent. The aqueous extract at dose 200 mg/kg showed maximum percentage reduction (61.39) and the results were comparable with that of reference standard Metformin HCl (61.61%).
Article Details
Unique Paper ID: 153401

Publication Volume & Issue: Volume 8, Issue 7

Page(s): 103 - 106
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