A REVIEW ON TOPICAL DRUG DELIVERY SYSTEM: PRONIOSOMAL GEL
Author(s):
SUNIL KUMAR, Dr. karunakar shukla2, DR SAURABH JAIL, DR ANUPAM KR SACHAN
Keywords:
Topical drug delivery, Coacervation phase separation, Vesicular drug delivery, Proniosomal gel, Non-ionic surfactants.
Abstract
The transdermal route of drug delivery has a number of advantages in terms of drug administration in both local and systemic therapy. Proniosomes, which are manufactured in dry form and then hydrated in hot water to create niosomes, offer a promising alternative for drug delivery via the transdermal route. However, when compared to other biological membranes, skin is well known for its effective barrier qualities. Dermal delivery is an alternative channel because of the skin's limited permeability, while dermal delivery is an alternative route. Poor bioavailability, variable absorption, and pharmacokinetic alterations are common side effects of newer lipophilic medicines. This proniosomal gel is a compact semi-solid liquid crystalline (gel) made up of non-ionic surfactants that may be easily created by dissolving the surfactant in the smallest amount of appropriate solvent, aqueous phase, and phosphate buffer. Topical application of gel in an occlusive environment, during which they are transformed to nisomes due to hydration by water in the skin. Proniosomal gels are usually semisolid gels with a transparent, translucent, or whitish texture, which keeps them physically stable throughout storage and transportation. The manufacture, formulation, assessment, and application of proniosome gel as a drug delivery carrier are all covered in this review.
Article Details
Unique Paper ID: 153444

Publication Volume & Issue: Volume 8, Issue 7

Page(s): 217 - 223
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