FORMULATION AND EVALUATION OF CETRIZINE FAST DISSOLVING TABLETS

FORMULATION AND EVALUATION OF CETRIZINE FAST DISSOLVING TABLETS
Author(s):
Saritha Chukka, Priya Kumari, Shankaraiah Puligilla
Keywords:
API, Fast dissolving tablet, Oral route, Excipients, superdisintegrants
Abstract
Orally disintegrating tablets (ODTs) are a rapidly growing category of dosage form in the pharmaceutical industry which has received ever-increasing demand during the last decade. They especially find application in target category like geriatrics and pediatrics. There are three main manufacturing methods used for the production of ODTs, namely, freeze drying, molding and compression method. Orally disintegrating tablets (ODTs) containing Cetrizine were prepared by direct compression method by using superdisintegrants such as crospovidone and croscarmellose. The prepared ODTs were characterized for their drug content, hardness, friability and wetting time. All the tablet formulations showed acceptable physicochemical properties and complied with the pharmacopoeial specifications for weight variation, drug content and friability. The optimized formulation (F4) was showed satisfactory results with drug release, and was physically stable during 3 months period.
Article Details
Unique Paper ID: 153591 Publication Volume & Issue: Volume 8, Issue 8 Page(s): 74 - 79
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