PASSIFLORA EDULIS LEAF EXTRACTS TOWARDS DRUG RESISTANT CANCER CELL
Author(s):
Giddla Leela Jacob, Dr. Kudipudi Harinadha Baba
Keywords:
PEL (Passiflora edulis leaves), PEF (Passiflora edulis fruit), PEP (Passiflora edulis Pericarp)
Abstract
Passiflora edulis, commonly known as passion fruits is a vine species of passion flower. It is cultivated commercially in tropical & subtropical areas for its sweet, seedy fruit. Fruit is berry type, oval to round, at maturity it is yellow to dark purple with juicy interior filled with numerous seeds. Passiflora Edulis L., Passifloraceae, leaves were collected in the city of Rajahmundry Andhra Pradesh, India. The leaves were air-dried at 45- 50 °C for 72 hours to 80hours, powdered, and stored at room temperature. Cytotoxicity of the studied samples In this study, we first screened the cytotoxicity of crude extracts belonging to plassiflora edulis plant towards drug-resistant cancer cells. The results are shown in Table 1. Plassiora Edulis plant extracts with IC50 values below of 20 µg/mL following incubation between 48 and 72 h are recognized as potential cytotoxic substances. In the present study, multi-factorial drug-resistant cancer cell lines such as leukemia. In this study, Passiflora edulis had good cytotoxicity against CCRF–CEM leukemia cells and its resistant subline CEM/ADR5000 cells. Their selectivity to these two cell lines, indicates that they can be sources for the development of novel anticancer drugs to fight leukemia.
Article Details
Unique Paper ID: 153938

Publication Volume & Issue: Volume 8, Issue 9

Page(s): 273 - 279
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