A Review on Synthesis of Nicotine
Sathe.M.P, Dr. Jain P.P, Dr. Kambale H.V
Iodination, Methylation, Nicotine, Psychoactive, Reduction, Vermifuge.
Nicotine, is the principal Alkaloid of tobacco plant. An alkaloid is one of a group of nitrogenous organic compounds that have marked physiological effects on humans. Nicotine occurs throughout the tobacco plant in the leaves. The compound constitutes about 5% of the plant by weight. The tobacco plant (Nicotiana tabacum) and the compound are named for Jean Nicot, a French ambassador, who sent tobacco seeds to Paris. Crude nicotine the compound was obtained in purified form in 1828, the right molecular formula was developed in 1843, and the first laboratory synthesis was reported in 1904. Nicotine is one of the fluid alkaloids. In its pure state it is a colourless, odourless liquid with an oily consistency, but when exposed to light or air, it acquires a brown colour and gives off a strong odour of tobacco. The present review is focused on the synthesis of nicotine by various methods. It is synthesized by three methods namely Iodine-Mediated Hofmann–Loffler Reaction, methylation and reduction.
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Unique Paper ID: 154265

Publication Volume & Issue: Volume 8, Issue 10

Page(s): 428 - 432
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