Review on the Synthesis and characterization of N-5{Acridin-9yl)-2-chloro phenyl}alkyl]aryl amides/imides possessing  Antimicrobial activity

Review on the Synthesis and characterization of N-5{Acridin-9yl)-2-chloro phenyl}alkyl]aryl amides/imides possessing Antimicrobial activity
Author(s):
RENU SINGH
Keywords:
Acridine derivatives, Animal charcoal, diphenyl derivatives.
Abstract
An equivalent mixture of Diphenylamine and 4-chloro benzoic acid was heated in the presence of anhydrous ZnCl2 in ethanol. After few hours crude was extracted with benzene, then boiled with charcoal, filtered to get 9-(4-chlorophenyl)-acridine crystal (I). A finally powdered mixture of (I) and an appropriate amido/ imido alkylol (II) was dissolved in concentrated sulphuric acid which furnished N-[5-acridin-9-yl)-2-chlorophenyl}alkyl]-aryl amides/imides(III). Compound (III) were screened for their antimalarial activity involving the standardized method as recommended by National Committee on Clinical Laboratory Standards (NCCLS).
Article Details
Unique Paper ID: 154330 Publication Volume & Issue: Volume 8, Issue 10 Page(s): 551 - 555
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