FORMULATION AND EVALUATION OF MEDICATED CHEWABLE TABLETS OF TRIAMTERENE
Author(s):
Bapurao S. ankalgi, Ashlesha S. Gaikwad, Harshada N. Ghogare, Aishwarya M. Dhane, Shreya S. Garde, Pooja K. Garad
Keywords:
Triamterene, Chewable tablets, Crospovidone and Sodium starch glycolate
Abstract
Chewable tablets are required to broken & chewed in between teeth before ingestion. These are usually uncoated. These are intended to be chewed in the mouth before swallowing and not intended to be swallowed directly . Chewable tablets are designed for use by the children and those persons who may have difficulty in swallowing the tablets. The objective is to develop efficient formulation of Triamterene chewable tablet. Triamterene is potassium-sparing diuretic used for the treatment of hypertension. Triamterene medicated chewable tablets are prepared by Wet Granulation method using two super-disintegrants i.e Crospovidone and Sodium Starch Glycolate. Total 6 formulations are prepared and the blend is evaluated for pre-compression parameters i.e angle of repose , bulk & tapped density, compressibility index & Hausner’s ratio. These formulated tablets are evaluated for Thickness, Diameter ,Hardness, Weight Variation, Disintegration, Friability and Drug Content. The result showed that all the physical parameters are within acceptable limits. From 6 formulations, formulation F4 is selected as promising formulation on the basis of In-Vitro drug release & In-Vitro dispersion time which is found to be 24.54±1.202 sec and 95.26±2.57 % respectively.
Article Details
Unique Paper ID: 155346

Publication Volume & Issue: Volume 9, Issue 1

Page(s): 1183 - 1193
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