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SYNTHESIS, CHARACTERIZATION, DNA BINDING, MOLECULAR DOCKING, CYTOTOXICITY AND ANTIMICROBIAL STUDIES OF TRANSITION METAL COMPLEX WITH IMINODIACETIC ACID AND 1-PENTADECANE CARBOXYLIC ACID

  • Unique Paper ID: 155953
  • Volume: 9
  • Issue: 2
  • PageNo: 366-378
  • Abstract:
  • The Cu(II) complex have been synthesized from the iminodiacetic acid and 1-pentadecane carboxylic acid (palmitic acid). The nature of bonding and geometry of the transition metal complex have been deduced from elemental analysis, FT-IR, UV–vis, emission, EPR spectral studies. UV–vis, cyclic voltammetry titrations, and viscosity measurements were used to investigate the Cu(II) complex's interaction with CT- DNA. The complex binds to DNA through intercalative binding mode. The experimental data were confirmed by molecular docking studies, employing DNA sequences bind with DNA via a minor groove mode of binding. The biological activity of the metal complex has been studied on bacteria pathogenic strains Enterobacter cloacae, Staphylococcus haemolyticus and Bacillus cereus and fungi Candida albicans and Aspergillus fumicatus by well diffusion method.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 9
  • Issue: 2
  • PageNo: 366-378

SYNTHESIS, CHARACTERIZATION, DNA BINDING, MOLECULAR DOCKING, CYTOTOXICITY AND ANTIMICROBIAL STUDIES OF TRANSITION METAL COMPLEX WITH IMINODIACETIC ACID AND 1-PENTADECANE CARBOXYLIC ACID

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