SYNTHESIS, CHARACTERIZATION, DNA BINDING, MOLECULAR DOCKING, CYTOTOXICITY AND ANTIMICROBIAL STUDIES OF TRANSITION METAL COMPLEX WITH IMINODIACETIC ACID AND 1-PENTADECANE CARBOXYLIC ACID

SYNTHESIS, CHARACTERIZATION, DNA BINDING, MOLECULAR DOCKING, CYTOTOXICITY AND ANTIMICROBIAL STUDIES OF TRANSITION METAL COMPLEX WITH IMINODIACETIC ACID AND 1-PENTADECANE CARBOXYLIC ACID
Author(s):
SHANMUGAM RAJALAKSHMI, VENKATESAN VINAYAGAM, MAHADEVIMANGALAM NARAYANASAMY ARUMUGHAM
Keywords:
Iminodiacetic acid, DNA binding, Viscosity, 1-pentadecane carboxylic acid (palmitic acid), Biological activity and cytotoxicity.
Abstract
The Cu(II) complex have been synthesized from the iminodiacetic acid and 1-pentadecane carboxylic acid (palmitic acid). The nature of bonding and geometry of the transition metal complex have been deduced from elemental analysis, FT-IR, UV–vis, emission, EPR spectral studies. UV–vis, cyclic voltammetry titrations, and viscosity measurements were used to investigate the Cu(II) complex's interaction with CT- DNA. The complex binds to DNA through intercalative binding mode. The experimental data were conﬁrmed by molecular docking studies, employing DNA sequences bind with DNA via a minor groove mode of binding. The biological activity of the metal complex has been studied on bacteria pathogenic strains Enterobacter cloacae, Staphylococcus haemolyticus and Bacillus cereus and fungi Candida albicans and Aspergillus fumicatus by well diffusion method.
Article Details
Unique Paper ID: 155953 Publication Volume & Issue: Volume 9, Issue 2 Page(s): 366 - 378
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