NANOCRYSTAL TECHNOLOGY, CHARACTERIZATION AND PHARMACEUTICAL APPLICATIONS
Author(s):
Amol Giri, Aijaz A. Sheikh, Arif Sheikh, R.H.Kale, K.R. Biyani
Keywords:
Drug nanocrystals, Drug delivery, stabilizers, Top-down techniques, Sterilization, Raman spectroscopy, Nanocrystal applications
Abstract
Today one of the greatest challenges in drug delivery is the poor solubility of new chemical entities. Approximately seventy to ninety percent of new chemical entities are having solubility issues. One relatively simple approach to improve drug dissolution and solubility properties is formulation as nanocrystals. Drug nanocrystals are solid nanosized drug particles surrounded by a stabilizer layer; sometimes they are also referred to as solid micelles. Typically, their size ranges from approximately 200 to 800 nm, depending on the application. Drug nanocrystals have comparatively simple structures which make them attractive for the formulation for poorly soluble drugs, and their capability to improve the dissolution in vitro is easily demonstrated. The present review basically deals with the nanocrystals, its physical properties, current technologies for producing drug nanocrystals i.e. top-down, bottom-up, and combinative. The review also focuses on sterilization, stability and characterization of nanocrystals with its pharmaceutical applications.
Article Details
Unique Paper ID: 156028

Publication Volume & Issue: Volume 9, Issue 2

Page(s): 1010 - 1017
Article Preview & Download


Share This Article

Conference Alert

NCSST-2021

AICTE Sponsored National Conference on Smart Systems and Technologies

Last Date: 25th November 2021

SWEC- Management

LATEST INNOVATION’S AND FUTURE TRENDS IN MANAGEMENT

Last Date: 7th November 2021

Latest Publication

Go To Issue



Call For Paper

Volume 8 Issue 4

Last Date 25 September 2021

About Us

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org

Social Media

Google Verified Reviews

Contact Details

Telephone:6351679790
Email: editor@ijirt.org
Website: ijirt.org

Policies

Important Links

Browse Rsearch papers