Design and Evaluation of Press-coated Chronomodulated Delivery of Indomethacin Tablets for Treatment of Rheumatoid arthritis

Design and Evaluation of Press-coated Chronomodulated Delivery of Indomethacin Tablets for Treatment of Rheumatoid arthritis
Author(s):
Tatikayala Ravikumar, Golla Chandramouli, Radapaka Avinash
Keywords:
Indomethacin, Eudragit RL100, HPMC K100M, and Arthritis
Abstract
The main objective of the present work is to design chronomodulated tablets of indomethacin by compression method. The press-coated tablet containing indomethacin in the inner core was formulated with an outer layer by varying ratios of both hydrophobic and hydrophilic polymers such as Eudragit RL 100 and HPMC K 100M. The prepared core and press-coat tablets were evaluated parameters like weight variation, hardness, thickness, friability, disintegration, core erosion test, and in vitro release studies. The release pattern of the press-coated tablet exhibited a period without drug release (lag time, 4hrs) followed by a rapid and complete release of the drug. The formulation (F3) core tablet showed 97% of drug release in 1 hr, whereas the press-coated formulation (F6) exhibits 97.64% in 6 hrs.
Article Details
Unique Paper ID: 156321 Publication Volume & Issue: Volume 9, Issue 3 Page(s): 328 - 331
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