Design and Evaluation of Press-coated Chronomodulated Delivery of Indomethacin Tablets for Treatment of Rheumatoid arthritis
Tatikayala Ravikumar, Golla Chandramouli, Radapaka Avinash
Indomethacin, Eudragit RL100, HPMC K100M, and Arthritis
The main objective of the present work is to design chronomodulated tablets of indomethacin by compression method. The press-coated tablet containing indomethacin in the inner core was formulated with an outer layer by varying ratios of both hydrophobic and hydrophilic polymers such as Eudragit RL 100 and HPMC K 100M. The prepared core and press-coat tablets were evaluated parameters like weight variation, hardness, thickness, friability, disintegration, core erosion test, and in vitro release studies. The release pattern of the press-coated tablet exhibited a period without drug release (lag time, 4hrs) followed by a rapid and complete release of the drug. The formulation (F3) core tablet showed 97% of drug release in 1 hr, whereas the press-coated formulation (F6) exhibits 97.64% in 6 hrs.
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Unique Paper ID: 156321

Publication Volume & Issue: Volume 9, Issue 3

Page(s): 328 - 331
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