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@article{156321,
        author = {Tatikayala Ravikumar and Golla Chandramouli and Radapaka Avinash},
        title = {Design and Evaluation of Press-coated Chronomodulated Delivery of Indomethacin Tablets for Treatment of Rheumatoid arthritis},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {9},
        number = {3},
        pages = {328-331},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=156321},
        abstract = {The main objective of the present work is to design chronomodulated tablets of indomethacin by compression method. The press-coated tablet containing indomethacin in the inner core was formulated with an outer layer by varying ratios of both hydrophobic and hydrophilic polymers such as Eudragit RL 100 and HPMC K 100M. The prepared core and press-coat tablets were evaluated parameters like weight variation, hardness, thickness, friability, disintegration, core erosion test, and in vitro release studies. The release pattern of the press-coated tablet exhibited a period without drug release (lag time, 4hrs) followed by a rapid and complete release of the drug. The formulation (F3) core tablet showed 97% of drug release in 1 hr, whereas the press-coated formulation (F6) exhibits 97.64% in 6 hrs.},
        keywords = {Indomethacin, Eudragit RL100, HPMC K100M, and Arthritis},
        month = {},
        }