Metal complexes of Schiff base derived from 3-bromo, 5-chloro Salicyldehyde with Alanine: characterization, Molecular Modeling and Antibacterial activity study
Bibhesh K Singh, Pinkee, Hament K. Rajor, Jagdish Chandra
Antibacterial activity, Metal complexes, Molecular modeling, Schiff base, Spectral studies,
Biologically active tridentate Schiff base ligand derived from 3-bromo-5-chloro salicyldehyde with alanine(DL-Alanine) and their Fe(II), Co(II), Ni(II) and Cu(II) complexes have been synthesized and characterized by physical and spectroscopic techniques. The vibrational spectrum suggests that the Schiff base ligand coordinated to the metal ions in a tridentate manner with ONO donor sites of the nitrogen atom of the imine group, oxygen atom of carboxaloto group and with phenolic oxygen to give an octahedral geometry. TOF-Mass spectrum explains the successive degradation of the molecular species and justified ML2 complex. Electronic spectra and magnetic properties of the complexes are consistent with the proposed octahedral geometry. The structure optimization by MM2 calculation supports an octahedral geometry of the complexes. The preliminary in vitro antibacterial activity of all the complexes at two different concentrations was screened against four bacterial pathogens namely, Streptococcus, Salmonella typhi, Staphylococcus aureus and Escherichia coli showed moderate activity and slightly higher compared to the ligand.
Article Details
Unique Paper ID: 156353

Publication Volume & Issue: Volume 9, Issue 3

Page(s): 471 - 478
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