Anticancer Studies on the Leaves and Stem bark of Cordia dichotoma G. Forst
Padmaa M Paarakh, Yakshitha M, Yakshitha V, Tilak Kumar M, Vadivel G, Swetha R
Anticancer activity; Total Phenol content; Total Flavonoid content; Cordia dichotoma; MTT Assay; Breast cancer cell lines.
The aim of the study was to evaluate anticancer activity of the methanol extract of leaves and stem bark of Cordia dichotoma G. Forst against a Human Breast Carcinoma Cell line(MDAMB231) by MTT assay. The coarse powder of leaf and stem were subjected to Soxhlet extraction using methanol and water as solvent. Phytochemical screening was performed to find out the secondary metabolite. Total Flavonoid and phenol content were determined by colorimetric method. The phytochemical screening of methanol and aqueous extract of leaf and stem bark showed the presence of alkaloids, flavonoids, tannins, carbohydrates, amino acids, saponins, steroids and triterpenoids. The total phenolic content and flavonoid content of methanol extract of leaf was 4.467µg/ml and 5.114µg/ml and stem bark was 4.739µg/ml and 4.762µg/ml respectively. The IC50 values of methanol extract of stem bark, aqueous extract of leaf and aqueous extract of stem bark were found to be 125μg/mL, 232.7μg/mL and 110.1μg/mL respectively in MDAMB231 cells in comparison to Standard Vincristine IC50 14.41µM whereas methanol extract of leaf did not possess any anticancer activity. This study suggests that Cordia dichotoma can be useful in the treatment of breast cancer.
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Unique Paper ID: 156432

Publication Volume & Issue: Volume 9, Issue 3

Page(s): 748 - 753
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