Evaluation of antihypertensive activity of Punica granatum linn. in high fat diet and Streptozotocin induced diabetes in rats
Swapnita Ashok koli, Pallavi Kakade , Srutuja Jadhav
Diabetes Mellitus is one of the most prevalent metabolic disorders charactrised with increased blood sugar level and improper primary metabolism. It is charactrised by alteration in metabolism of carbohydrate, fat and protein, which are caused by inappropriate secretion of insulin or insulin resistance. The number of people with diabetes is increased due to population growth, aging, urbanization and increasing prevalence of obesity and physical inactivity (Firdous et al., 2016). Type 1 it is also called as Insulin Dependent Diabetes Mellitus (IDDM). It is due to failure of body for insulin production. It is often childhood disease so it is also called as Juvenile onset diabetes mellitus. In other words, it is a non-autoimmune, complex, heterogeneous and polygenic metabolic disease condition in which the body fails to produce enough insulin, characterized by abnormal glucose homeostasis. Its pathogenesis appears to involve complex interactions between genetic and environmental factors. It occurs when impaired insulin effectiveness is accompanied by the failure to produce sufficient ß-cell insulin (Shivasankar et al, 2011). .Type 2 it is also called as Non Insulin Dependent Diabetes Mellitus (NIDDM). In this type cells are unable for insulin usage. The other name of this type is adult onset diabetes mellitus (Soni, 2013). Type 2 diabetes is often, but not always, associated with metabolic abnormalities such as obesity, which itself can cause insulin resistance and lead to elevated blood glucose levels. Whereas type 2 diabetes is thought to be primarily heterogeneous and polygenic with low penetrance for the variants discovered, there exist monogenic types of non-autoimmune diabetes showing a Mendelian dominant pattern of inheritance, of which maturity-onset diabetes of the young (MODY) is the most common type 2 (Hertel, 2012).
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Unique Paper ID: 156668

Publication Volume & Issue: Volume 9, Issue 4

Page(s): 393 - 430
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