Solid Lipid Nanoparticles - An Emerging for Ocular Drug Delivery System
Author(s):
DR. C. SENTHIL KUMAR, R. PREMA, P. CHANDRASEKAR, P. PREMKUMAR, R. BINO KINGSLEY, K. VENKATESHWARAN
Keywords:
Solid Lipid Nanoparticles (SLNs), Nanostructured Lipid Carriers, Controlled Release, Lyophilization and Surfactants.
Abstract
Drug delivery to the eye remains a complex process due to the nature and structure of the eye. Conventional dosage forms such as eye drops and ointments are inefficient in therapeutics, because they possess low bioavailability and sometimes exhibit toxicity. So, there is a need to develop novel drug delivery carriers to increase ocular bioavailability and decreased local and systemic toxicity. Nanotechnology is one of the best approaches for ocular drug delivery. Many nano-structured systems have been employed for ocular drug delivery to get better results. One of the best nano structure development is Solid Lipid Nanoparticles (SLNs). It is the best drug carrier system since 1991. SLNs are mainly used in ocular drug delivery because they increase corneal absorption and bioavailability of both hydrophilic and lipophilic drugs as they are prepared by physiological lipids. SLNs are mainly prepared by allowing autoclave sterilization, which is a major step for formulation of ocular preparations. This review gives the detailed note on various methods of preparation, characterization, sterilization and evaluation of SLNs. This also gives a note on nature of lipids and surfactants used in SLNs preparation.
Article Details
Unique Paper ID: 156692

Publication Volume & Issue: Volume 9, Issue 4

Page(s): 516 - 526
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