Pharmacological screening of Ampelocissus latifolia leaves for impaired wound healing and antimicrobial potential
Author(s):
Mrigendra singh , Rajesh singh pawar, Hargovind garg
Keywords:
Wounds healing, Ampelocisus latifolia, Antimicrobial, Microbial infection, Wound infections
Abstract
Microbial infection and Wound infections are most common in developing countries because of poor hygienic conditions. Staphylococcus aureus, Streptococcus pyogenes, Corynebacterium spp, Escherichia coli, and Pseudomonas aeruginosa are some important organisms causing wound infection. Infected wounds heal more slowly and have an increased incidence of scarring. P. aeruginosa is the predominant organism, which causes air born infection and its frequency of infection is more in burn patients. A wide range of antibiotics is available for treatment of wound infections, but they are now proved to have adverse effects in the human body, also these pathogens developed resistance to the antibiotics targeted against them. Researchers paid much attention on extracts of biologically active compounds isolated from plant species used in herbal medicine. A number of researchers worked on various parts of Ampelocissus latifolia species for a number of activities. This study focused on evaluation of methanolic extract of Ampelocissus latifolia leaves on antimicrobial and wound healing activity. The crude extraction was carried out using methanol. Antimicrobial activity of the extract was carried out against gram negative bacteria (Escherichia coli) and gram positive bacteria (Staphylococcus aureus) by disc diffusion assay. The crude extract was prepared in 5% (w/w) and 10% (w/w) ointment and evaluated for wound healing activity using excision wound models in rats. The methanolic extracts of Ampelocissus latifolia were found to possess significant wound-healing activity, which was evidenced by increase in the rate of wound contraction. The present study has demonstrated that the methanolic extract of A. latifolia have properties that render them capable of promoting accelerated wound-healing activity compared with placebo control.
Article Details
Unique Paper ID: 157035

Publication Volume & Issue: Volume 9, Issue 5

Page(s): 783 - 789
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