OXCARBAZEPINE INDUCED HYPONATREMIA: A CASE REPORT

OXCARBAZEPINE INDUCED HYPONATREMIA: A CASE REPORT
Author(s):
ASHIMA BASHEER, RITTU R.L, DR.DHANYA DHARMAN, Dr.Shaiju S Dharan
Keywords:
Hyponatremia, SiADH, Adverse effects, Anti-convulsant
Abstract
Oxcarbazepine is a well-known and effective anti-convulsant used for patients with underlying seizure disorder. It is a structural analog of carbamazepine, it follows a different metabolic pathway in which it is converted to a different active metabolite. Side effects associated with this medication are vast, in this report we will look in on the renal adverse effects, Syndrome of inappropriate anti-diuretic hormone secretion (SiADH). SiADH is a condition in which the body is making too much anti-diuretic hormone which results in too much water absorption and cause hyponatremia with neurologic sequelae. Here is a 67-year-old female patient with complaint of increased talk, insomnia for 3 months. On admission in hospital under psychiatry the patient was treated with T.Zenoxa (Oxcarbazepine) 450mg 1-0-1 and on following days patient Na decreased 135, 130, 124 mEq/L which indicated to be hyponatremic secondary to having SiADH.
Article Details
Unique Paper ID: 157252 Publication Volume & Issue: Volume 9, Issue 6 Page(s): 365 - 367
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