Effect of Antidiabetic drug on thyroid function and vascular dysfunction in diabetic rat with methimazole induced hypothyroidism.
Author(s):
Ankita Sarode, Aaishwarya Deshmukh , Dr. S. R. Chaudhari
Keywords:
Diabetes mellitus, cardiovascular dysfunctioning, thyroid hormones, hypothyroidism, SGLT2 inhibitors.
Abstract
Cardiovascular dysfunctiong in type 2 diabetic patients has interlinked with presence of thyroid hormone dysfunctioning and is one of the leading diabetic complication. SGLT2 inhibiters are seen to have its effect in controlling cardiovascular dysfunctioning as well as imbalance in thyroid hormone levels respectively. Our work aims to elucidate the effect of Dapagliflozin in cardiovascular dysfunctioning and its activity on thyroid hormone levels on diabetic rats induced with hypothyroidism by determining LDH levels and T3, T4, and TSH levels. Methods: T2DM was induced with a single intraperitoneal (i.p.) injection of freshly prepared streptozotocin (35 mg/kg), 15 min after intraperitoneal injection of nicotinamide (230 mg/kg). Commercially available kits were used to measure thyroid hormone levels and cardiac marker level. Results: Significant decrease in blood glucose levels were observed 14 days after initial administration in diabetic and hypothyroid treated with dapagliflozin and diabetic treated with dapagliflozin groups compared with diabetic group. After 4 weeks of dapagliflozin treatment, lactate dehydrogenase (LDH) levels and thyroid hormone stimulating (TSH) levels were significantly decreased as compared to diabetic group. Moreover, T3 and T4 levels were increased significantly dapagliflozin treated groups compared with a diabetic group. Dapagliflozin treatment also normalised the general symptoms of diabetes. Conclusion: The study has revealed that, SGLT2 inhibitors demonstrated to impart major cardiovascular safety on T2DM induced rats mainly by decreasing LDH levels in body.
Article Details
Unique Paper ID: 157253

Publication Volume & Issue: Volume 9, Issue 6

Page(s): 405 - 410
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