Formulation & Evaluation of tablet based on solid dispersion of antihistaminic drug
Author(s):
Tabassum Bano, MD Abdul aali khan
Keywords:
Tablet, Orodispersible Tablet, Antihistaminic Activity.
Abstract
In this Study Orodispersible tablets of Cimetidine was prepared by compressing granules that were successfully prepared by wet granulation method with sodium starch glycolate and crosspovidone as superdisintegrant and other excipents like camphor, mannitol, polyvinylpyrrolidine, Talc and Mg stearate. Preformulation studies of the drug were performed first and the results were found to be the drug is white in colour and odourless. The solubility of the drug was found to be it is soluble in water and 0.1 N HCl, sparingly soluble in dimethyl sulfoxide and insoluble in chloroform and methanol. The melting point and partition coefficient were determined by open capillary method and phase separation method. The melting point and partition coefficient of the drug were found to be 140˚C and 2.4.The UV absorbance’s of Cimetidine standard solution in the range of 5-50 µg/ml of drug in water showed linearity at λ max 218nm. The linearity was plotted for absorbance against concentration with R2 value 0.973 and with the slope equation y = 0.032x + 0.011.A granule prepared by wet granulation was subjected to the evaluation of their flow property like angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio. The results were found to be in the limits. After mixing the powder with appropriate characteristics and flow property, tablets were made by direct compression method in a single punch machine. All the prepared tablets were evaluated for the test like hardness, friability, weight variation, disintegration time, drug content and dissolution studies. Hardness friability was found to be in limits.According to the European Pharmacopoeia standard for orodispersible tablets,
Article Details
Unique Paper ID: 157321

Publication Volume & Issue: Volume 9, Issue 6

Page(s): 712 - 719
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