Anticancer Activity of Magnetic Iron Oxide Nanoparticles Synthesized Using Anacardium Occidentale Leaf Extract
Author(s):
Ashlin Rose, Dr.K. R Sheeja
Keywords:
Anacardium Occidentale, Anticancer, Green approach, Magnetic nanoparticles.
Abstract
Iron Oxide nanoparticles were synthesized using extract of Anacardium Occidentale leaves which act as reducing as well as capping agents, and Ferric Chloride as a precursor. The Iron Oxide nanoparticles have been characterized using UV-Visible, FT-IR, SEM, TEM, EDAX and X-Ray diffraction studies. Anticancer activity of Iron Oxide nanoparticles was carried out against breast cancer cell (MDA-MB-231) and Skin cancer (SKMEL) cell lines. MTT assay identified significant anticancer activity of the nanoparticles against both cell lines. The result has shown that the Iron nanoparticles are crystalline with sizes ranging from 15 to 20 nm. Dose dependant reduction in cell viability were observed in breast cancer cell (MDA-MB-231) and Skin cancer (SKMEL) cells with different concentrations of the Iron Oxide nanoparticles. Viability percentage were reducing significantly and the IC50 value of Iron Oxide nanoparticles against Skin cancer cells were found to exhibit 35.35 µg/ml. This present study revealed that the successful green synthesis and characterization of Iron Oxide nanoparticles having excellent anticancer activities.
Article Details
Unique Paper ID: 157388

Publication Volume & Issue: Volume 9, Issue 6

Page(s): 4 - 9
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