FORMULATION AND EVALUATION OF HYDROGEL WITH SALICYLIC ACID USING ALOEVERA POWDER AS DRUG CARRIER
Author(s):
Amruta Ankush Nangare, Ashish A. Jagtap, Hemant S. Kandle, Atul R. chopade, Sangram S. Patil
Keywords:
Hydrogel, salicylic acid, Aloe Vera, bioavailability.
Abstract
The purpose of this study is to develop a controlled-release hydrogels and evaluate their drug delivery efficiency. Synthetic polymeric drug carriers are safely metabolized but offer no health benefits unlike the natural carriers such as starch an d Aloe Vera. Therefore, in this study, the in-vitro release properties of ascorbic acid-based hydrogel formulated using aloe vera gel powder as drug carrier and nutritional enrichment excipients were used. Methods: Hydrogels are a recent approach for sustained drug delivery and are advantageous because of their unique drug release patterns such as swelling and diffusion. Vitamin C is a well known antioxidant that scavenges free radicals and Aloe Vera i ncreases the bioavailability of vitamin C and protects it from degradation along with other essential properties. Results: Various evaluation parameters have been carried out such as swelling studies and in-vitro release studies. These evaluation studies results have shown that maximum swelling percentage was seen at pH 1.4 and least in distilled water which imparts that even in acidic medium the formulated hydro gel can outlive. Appreciable swelling was seen in pH 5.4 and 7.4. Furthermore, the hydro gel was seen to undergo disintegration in distilled water. Conclusion: The in-vitro release studies showed that the drug was released at a predetermined rate over a controlled period of time hence it can be used in sustained drug delivery. The materials used in this study are bioavailable and biocompatible so they will not impart any toxicity and side effects.
Article Details
Unique Paper ID: 158115

Publication Volume & Issue: Volume 9, Issue 8

Page(s): 676 - 680
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