FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF VENLAFAXINE HCl

FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF VENLAFAXINE HCl
Author(s):
Botla Manohar, Pranay Renukuntla, Daniel Kothapally
Keywords:
Venlafaxine HCl, HPMC, sustained release, and direct compression
Abstract
The sustained release tablets of venlafaxine HCl were prepared by direct compression method using release retarding ability of different grades of HPMC polymers (E4M, E15LV & E50LV) and eudrgit L 100 to extend the release of drug over 24hrs period and thereby improve its bioavailability. The developed tablets were evaluated for pre-compression and post-compression parameters. The results of all formulations were found within the pharmacopeial limits. The optimized formulation (F7) with HPMC E50LV showed the maximum percentage of drug release for 24 hrs was 99.76%. The results indicated that at higher viscosity grades of polymer concentrations drug release was retarded greatly were observed. The drug release was showed by higuchi model followed by zero order release.
Article Details
Unique Paper ID: 158123 Publication Volume & Issue: Volume 9, Issue 8 Page(s): 742 - 746
Article Preview & Download

Share This Article

NCSST-2023

AICTE Sponsored National Conference on Smart Systems and Technologies

Last Date: 25th November 2023

LATEST INNOVATION’S AND FUTURE TRENDS IN MANAGEMENT

Last Date: 7th November 2023

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org