A medicinal plant known as Holoptelea integrifolia includes phytoconstituents like betulin and betulinic acid, which have been proven to have potent antiviral properties against the pandemic SARS-CoV-2 virus using in-silico screening study.
Sudhanshu Kumar Jha, Ravindra Kumar, Lalit Rana, Alvina Alam, Vikas Sonkar, Md. Imran Khan, Jitesh Raghav Sharma, Kadir Khan
Betulin, Betulinic acid , zanamivir, SARS CoV-2, Zanamivir, Phytoconsitutents.
In the current study, potential inhibitors for many physiologically active compounds discovered in medicinal plants were assessed using molecular docking techniques. The Maestro 12.8 conducted a docking study comparing the antiviral drug Zanamivir with phytoconstituents present in the stem bark of Holoptelea integrifolia, including betulin and betulinic acid. The results demonstrate the effectiveness of this screening methodology, which can speed the creation of new medications for the treatment of developing infectious diseases and other conditions. When compared to the antiviral drug Zanamivir, whose docking score was 3.796, PDB ID (6LU7) is taken as a major binding receptor. Phytoconstituents screening chemicals extracted from the medicinal plant Holoptelea integrifolia, such as betulin (-1.589) and betulinic acid (-1.552), were more effective than the typical antiviral medication zanamivir, whose docking score was 3.796. The docking results show that phytoconstituents in Holoptelea integrifolia plants are highly potent against viral diseases, are effective against SARS CoV-2, and can be used to prevent the spread of covid. As a result, they will be a crucial source for new antiviral medications in the future that target various viral diseases.
Article Details
Unique Paper ID: 158439

Publication Volume & Issue: Volume 9, Issue 9

Page(s): 471 - 481
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