Development and evaluation of bioflexy films phoenix dactylifera with topiramate by translabial drug delivery system
Author(s):
Swetha k, Padmapreetha J, Ardra krishna P V, Navyasree S M, Pradeepa R, Neethu K C, Keerthana R, Kavya G
Keywords:
Abstract
Formulation and evaluation of nanosized Topiramate loaded bio-flexy films using novel biopolymer isolated from phoenix dactylifera for epilepsy treatment, by using Translabial route. Translabial drug delivery system is an attractive approach for drug delivery system possess advantages as a bypass of the first-pass metabolism, prevent from digestive enzymes and rapid action of suitable drugs. The isolated biopolymer was subjected to various physicochemical characterization procedures for analyzing the mucoadhesive and mucoretentive properties. The mucoadhesive and mucoretentive properties of isolated biopolymer were analysed using the shear stress method and the MS mucoretentibility method. Methods: Formulations containing nanosized Topiramate: phoenix dactylifera biopolymer (in ratios of 1:0.5, 1:1; 1:3, 1:5, 1:6, 1:10) (FGO1-FGO6) were prepared by solvent casting method.
Article Details
Unique Paper ID: 158488

Publication Volume & Issue: Volume 9, Issue 9

Page(s): 621 - 625
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