Introducing hydrochlorothiazide drug for solubility enhancement by Novel hybridization technique
Keerthana R, Dinesh Raja A, Rajeshwari V, Sona M, Kanisma R M , Swarna Mallika K , Naveen Kumar S , Vignesh R
Solubility enhancement of Hydrochlorothiazide drug by novel hybridization technique that has a combinational approach of complexation and liquisolid technique. A complex of hydrochlorothiazide -captisol (1:1 molar ratio) is dispersed in the non-volatile solvent & then the carrier was added into mortar and pestle and then it is mixed with it for 10 to 20 min. Then coating materials are completely mixed with the above mixture to form a free-flowing powder. This free-flowing powder is mixed with other excipients & compressed into tablets by using a tablet compression machine using the same components. This technique also improves the drug release of poorly soluble drugs. Hydrochlorothiazide-Captisol inclusion complex is taken in different ratios (1:1, 1:2 & 1:3).Saturated solutions in 7.4 pH phosphate buffer were prepared. The filtered supernatants were further diluted if necessary with 7.4 pH phosphate buffer and analyzed spectrophotometrically using a UV/visible spectrophotometer (Shimadzu). The solubility of Hydrochlorothiazide in Hydrochlorothiazide-captisol inclusion complex is calculated using the Hyrochlorothiazide calibration. The ratios are compared with one another to find the highest solubility rate.
Article Details
Unique Paper ID: 158509

Publication Volume & Issue: Volume 9, Issue 9

Page(s): 698 - 702
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