Review on ethosomes: a novel carrier for transdermal delivery system

Review on ethosomes: a novel carrier for transdermal delivery system
Author(s):
MAHASHWETHA S S
Keywords:
Ethosomes, Transdermal, Ethanol, Phospholipids
Abstract
Oral route is the normal route of drug delivery, which has many benefits such as easy delivery but has drawbacks such as low bioavailability and a propensity to produce rapid spikes in blood levels, thereby being a requirement for higher dose or repeated dosing, which is difficult for the patient and also high cost. With all these disadvantages in mind, there is a need for novel drug delivery technology with increased therapeutic efficacy and safety with controlled delivery to minimize the size and number of doses. This can be achieved by transdermal delivery which possesses several advantages such as avoids first-pass metabolism, eliminates gastrointestinal irritation reduces frequency of dosing, and rapid termination of drug action. Ethosomes have higher penetration rate through skin due to its ethanolic content. In this article reviews various aspect of ethosomes including their mechanism of penetration, preparation, advantages, characterization, composition, preparation. These carriers open new challenges and opportunities for the development of novel improved therapies.
Article Details
Unique Paper ID: 158515 Publication Volume & Issue: Volume 9, Issue 9 Page(s): 18 - 23
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