Insulin Paving Way to Breast Cancer and Its Current Clinical Therapies
Ashwin Ram R, Dr. G. Ariharasivakumar, Vanitha N, Shanmuganathan D K, Tamilarasan M
Insulin, Breast cancer, PI3K, and MAPK.
The world booms with insulin and its alarming diseases. Insulin is secreted from islets of Langerhans and regulates various metabolic processes, facilitates glucose uptake, and promotes cell division. Several protooncogenes are mutated to an oncogene by various signaling pathways in which insulin paves a major role in increasing the risk for initiation of developing varied solid tumors, especially in larger women’s diabetic populations. Insulin involves mainly in two signaling pathways include PI3K and MAPK pathways. Activation of these pathways leads to glucose and lipid homeostasis, inhibition of the proapoptotic pathway, translocation of GLUT-4 receptor to membrane and fat to increase glucose uptake, and inhibition of glycolysis and gluconeogenesis. Among Luminal A & B and TNBC types PI3K and MAPK pathway mainly involves in the proliferation of survival translation, these are regulated by tumor suppressor genes such as p53, PTEN, BRCA1 & BRCA2.
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Unique Paper ID: 158525

Publication Volume & Issue: Volume 9, Issue 9

Page(s): 709 - 713
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