Insilico or organ on chip in Pre-Clinical and Clinical Trials

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Neharika Anike; Swathi Jaggannolla; Nikky Bhedi

Insilico or organ on chip in Pre-Clinical and Clinical Trials

Authors: Neharika Anike, Swathi Jaggannolla, Nikky Bhedi

Unique Paper ID: 158862
Volume: 9
Issue: 10
PageNo: 824-835

Keywords: Organ on a chip Lab on chip Biomimetic system Microfluidic chip Physiological models Drug development Toxicology

Abstract:
The organ-on-a-chip (OOAC) refers to a physiological organ biomimetic system built on a microfluidic chip. It involves biomaterial technology, cell biology and engineering combined together in a miniaturized platform. This reflects the structural and functional characteristics of human tissue and can predict response to an array of stimuli including drug responses and environmental effects. In this review, we introduce the concepts of OOAC and its application to the construction of physiological models, drug development, and toxicology from the perspective of different organs. We further discuss existing challenges and provide future perspectives for its application. These 'organs-on-chips' permit the study of human physiology in an organ-specific context, enable development of novel in vitro disease models, and could potentially serve as replacements for animals used in drug development and toxin testing.

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Cite This Article

ISSN: 2349-6002
Volume: 9
Issue: 10
PageNo: 824-835

Insilico or organ on chip in Pre-Clinical and Clinical Trials

Available:https://ijirt.org/article?manuscript=158862

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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