An overview on various nano- formulations of resveratrol in combination with different drugs for the treatment of HCC
Author(s):
Ankita Raut, Triveni Turre, Anirudha Ghete, Dr. Atul Hemake, Dr.Milind Umekar
Keywords:
Resveratrol, Nanoparticle, HCC, Polyphenol, Anticancer.
Abstract
Liver cancer remains a serious threat to global health, and its prevalence is increasing worldwide. Its causes include, among other factors, exposure to the C or B hepatitis viruses, alcohol use, smoking, obesity, nonalcoholic fatty liver disease, diabetes, and oxidative stress. There are other primary liver cancer types, but hepatocellular carcinoma will be our main focus (HCC). Naturally occurring bioactive food components such as polyphenolic compounds, for example, have demonstrated good antioxidant activity and show promise for use in the prevention of cancer. Since it has a broad spectrum of medicinal activities, including its anticancer, anti-inflammatory, and antioxidant properties, resveratrol, a natural polyphenol and phytoalexin, has received a lot of interest in the last 10 years. It has been shown that resveratrol suppressed HCC cell growth in a dose-dependent manner in both anchorage-dependent and independent conditions. However, its limited therapeutic value is due to its weak water solubility, poor chemical stability, and short biological half-life. Poor pharmacokinetics and low potency appear to be the two main bottlenecks of resveratrol among the many restrictions. To accelerate the transition of resveratrol from the laboratory to the bedside, new perspectives and tactics have been put forth. The most promising strategy in the meantime is to improve resveratrol bioavailability through novel formulations. As an alternative, stronger resveratrol analogues could be created to increase the substance’s anticancer effectiveness. The physicochemical features of resveratrol, the therapeutic potential of resveratrol nano-formulations, and the anticancer efficacy of resveratrol encapsulated n nanoparticles on hepatocarcinoma and various malignancies are the key topics of this paper.
Article Details
Unique Paper ID: 159131

Publication Volume & Issue: Volume 9, Issue 11

Page(s): 586 - 597
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