Synthesis, Characterization, DNA Binding, Antimicrobial activity, Cytotoxicity, DFT and Molecular Docking of Copper (II) Complex Containing L-Phenylalanine and 2, 9-dimethyl-1, 10-phenanthroline
E. G. Sundararaman, Dr. M. N. Arumugham
Copper (II) complex, L-phenylalanine, 2, 9-dimethyl-1, 10-phenanthroline, DNA binding, Cytotoxicity, Antimicrobial activity, DFT and Molecular docking studies.
New copper (II) complex, [Cu(dmp)(L-phe)(H2O)](NO3)(3H2O), where dmp. = 2, 9-dimethyl-1, 10-phenanthroline and L-phe = L-phenylalanine, has been synthesized and characterized by elemental analysis, UV-visible, FT-IR, ESI-MASS, EPR spectroscopic techniques. The optimized structure of present copper (II) complex was obtained by using the DFT/UB3LYP/6-31G (d.p)/LANL2DZ level of theory. Binding interactions of the copper (II) complex with calf thymus DNA (CT-DNA) was investigated by UV–Visible absorption titration, fluorescence, cyclic voltammogram studies, and viscometric titration experiments. The copper (II) complex was subjected to in-vitro cytotoxicity studies against breast cancer cell lines (MCF-7). The anticancer activity of copper (II) complex IC50 values are less than that of Cis-platin against MCF-7 cell lines. The antimicrobial activity of copper (II) complex was carried out using disc diffusion method against different species of pathogenic bacteria and fungi. Binding ability of the synthesized compound results was showen in molecular docking studies.
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Unique Paper ID: 159813

Publication Volume & Issue: Volume 9, Issue 12

Page(s): 579 - 595
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