FORMULATION AND EVALUATION OF LISINOPRIL AS FAST DISSOLVING TABLET
Author(s):
Dr. Keerthi G S Nair, Dr. Shaiju S Dharan, Dr. Sathesh Kumar S
Keywords:
Fast dissolving tablets, Lisinopril, Superdisintegrant, Direct compression, Sodium starch glycollate, Crosscarmellose sodium, Crosspovidone
Abstract
The objective of this research was to formulate fast dissolving tablets of Lisinopril that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Lisinopril is a drug widely used in the treatment of hypertension, congestive heart failure, heart attacks and in preventing renal and retinal complication of diabetes by inhibiting angiotensin converting enzyme (ACE). Fast dissolving tablets of Lisinopril were prepared by direct compression method comprising of three different super disintegrants- Sodium starch glycollate, Crosscarmellose sodium and Crosspovidone (4%, 7%, and 10%). The prepared batches of tablets were evaluated for hardness, thickness, friability, weight variation, drug content, in vitro disintegration time, in vitro dispersion time, wetting time, water absorption ratio and in vitro dissolution studies. FTIR studies revealed that there was no chemical interaction between the drug and the excipients. Based on evaluating parameters, formulation prepared by using 10 % cross povidone was selected as the best formulation. Stability studies were carried out at 250C ± 20C / 60% ± 5% RH and 400C ± 20C / 75% ± 5% RH for formulation F9 for 60 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, wetting time, and in vitro drug release.
Article Details
Unique Paper ID: 159962

Publication Volume & Issue: Volume 9, Issue 12

Page(s): 1435 - 1445
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