Phenotypic Screening in Drug Discovery

Phenotypic Screening in Drug Discovery
Author(s):
Yogesh Hadal, Preeti Kulkarni, Shivam Amare, Bhakti Patil, Bhaskar vaidhun
Keywords:
Chemical screening, In vitro assay, In vivo assay, Phenotypic screening
Abstract
In most cases, phenotypic screening has resulted in the invention of novel drugs. Compounds are distinct cell or creature sickness models used to identify intensities that induce a beneficial alteration in aggregate. Only after the mixtures have been invent are efforts undertaken to detect the mixtures' natural focuses - a cycle known as target deconvolution. More recently, it has been well known to cultivate a hypothesis that a specific organic objective is infection changing, and after that screen for intensifies that modify the action of this cleansed target. Following that, these mixes their testing was carried out on animals whether changes are occurred. This method is referred to as "switch pharmacology" or "target based drug revelation". Late quantifiable evaluation, however, reveals that phenotypic screening produces a disproportionate number of first-in-class medications with unique systems of activity, prompting a resurgence of interest in this technique.
Article Details
Unique Paper ID: 161327 Publication Volume & Issue: Volume 10, Issue 3 Page(s): 307 - 311
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