Design and In-vitro Characterization of Domperidone Oral Thin Films
Angilicam Avinash , DASARI DEEPTHI
Domperidone, sodium alginate, xanthan gum and PVP K30.
Domperidone is a medication used as an antiemetic, gastric prokinetic agent, and galactagogue. It may be taken by mouth, and is available as a tablet, orally disintegrating tablets, suspension, and suppositories. The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin. In present study oral thin films of Domperidone were developed to have a faster on set of action. The oral thin films were developed by using polymers sodium alginate, xanthan gum and PVP K30. Oral thin films were prepared by employing solvent casting method. Propylene glycol was selected as permeation enhancer and plasticizer. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F6, and all the formulations were evaluated for various physical parameters Physical appearance, Weight variation, Thickness, Folding endurance, Tensile strength, Drug content, Moisture uptake, Moisture content and all the results were found to be were found to be within the pharmacopeial limits, in-vitro drug release studies by using dialysis membrane. Among all the 6 formulations F5 formulation which contain PVP K30 50 mg and shown 98.06% cumulative drug release within 30 min. And compared to sodium alginate, xanthan gum and PVP K30, sodium alginate showed better drug release profile.
Article Details
Unique Paper ID: 161440

Publication Volume & Issue: Volume 10, Issue 4

Page(s): 61 - 67
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