Promethazine Syrup Banned: Alteration of Glycerine By The Diethylene Glycol And Ethylene Glycol
Author(s):
Samruddhi Babanrao Patil, Sanika.S.Patil, Dr.Pankaj.S.Kore, Shreya.V.Patil
Keywords:
Promethazine, Glycerine, Alteration, Banned, Diethylene Glycol, Ethylene Glycol.
Abstract
The World Health Organization (WHO) intervened after an increase in acute kidney injury cases among children under five in late July 2022, due to the toxic chemical contamination of Promethazine syrup, which contains diethylene glycol and ethylene glycol, leading to 66 deaths in The Gambia. Diethylene Glycol (DEG) is a cost-effective, sweet-tasting industrial solvent commonly used in antifreeze solutions and pharmaceutical products like tooth paste, injectable medications, fever cures, and cough syrup, replacing more expensive compounds like glycerin and propylene glycol. Diethylene glycol (DEG), a substance linked to numerous medication-associated mass poisonings, can pose a significant risk to the kidneys and nervous system when consumed. Ethylene glycol, used in solvents, hydraulic fluids, and antifreezes, can cause health issues like central nervous system depression, cardiac effects, and kidney impairment when consumed in large amounts. Ethylene glycol is a colorless, sweet-tasting substance that is mostly found in antifreeze but is also occasionally used to manufacture industrial solvents. Ingestions, whether intentional or unintentional, are usually the cause of exposures. Intentional exposures might be motivated by the desire to self-intoxicate or by a suicide attempt in the absence of ethanol, although accidental hazardous exposures are more common due to its sweet flavor.
Article Details
Unique Paper ID: 161882

Publication Volume & Issue: Volume 10, Issue 6

Page(s): 414 - 419
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