Overview on Controlled Drug Delivery System
Author(s):
Abhishek Pravin Patil, Adesh Bhanudas Ghadage, Ms. Radhika. S. Subhedar, Dr. Nilesh. B. Chougule
Keywords:
controlled release, dissolution, diffusion, polymers, oral, parenteral, matrix, encapsulation, reservoir, ionisation, dissociation.
Abstract
Controlled Drug Delivery Systems (CDDS) have revolutionized pharmaceuticals by enabling precise control over drug release within the body. Beginning in the mid-20th century with basic sustained-release formulations, CDDS has progressed significantly, encompassing various types like reservoir, matrix, and targeted systems. These systems employ diverse approaches such as diffusion-controlled, stimuli-responsive, and implantable devices to regulate drug delivery. Polymers play a pivotal role in CDDS, influencing release kinetics. Both natural (e.g., chitosan) and synthetic polymers (e.g., PLGA) are utilized, determining release rates based on their biodegradability and compatibility with drugs. Design and performance of CDDS depend on multiple factors including drug characteristics, choice of polymers, device design, and environmental conditions. The advantages of CDDS include improved therapeutic outcomes, reduced side effects, and enhanced patient compliance. However, challenges like complex manufacturing processes and potential issues like dose variability exist. The future of CDDS holds promise in personalized medicine, nanotechnology-driven smart drug delivery, and bioengineered systems, paving the way for highly tailored therapies and further advancements in healthcare.
Article Details
Unique Paper ID: 162223

Publication Volume & Issue: Volume 10, Issue 8

Page(s): 543 - 551
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