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A Review On: Principle, Types, Methods and Application of Gene Therapy

  • Unique Paper ID: 162266
  • Volume: 10
  • Issue: 9
  • PageNo: 51-56
  • Abstract:
  • Gene therapy is a novel approach to treat, cure or prevent disease by changing the expression of a person's genes. For the disease which do not curve by medicine or treatment that is curved by gene therapy which produce excitement, the controversy surrounding the altering of human imperfection, and the promise of a type of medical treatment most of us would never imagine possible. This is one of the best way to treat hereditary diseases by altering and correcting the genes. Nucleic acids is introduced into cells has as a purpose of medical condition or disease. Currently, gene therapy studies a broad range of potential therapeutic interventions, including the body's immune reaction to tumors, new blood vessels in the heart to alleviate heart attacks and to stop HIV-replication in patients with AIDS. There is also renewed emphasis on the gene therapy of genetic diseases, such as haemophilia A and B, and cystic fibrosis. Human gene therapy experimentation raises many issues. In this review article, background of gene therapy, introduction, genetic diseases, gene function, germ line gene therapy, hurdles in gene therapy, methods for gene therapy, ex vivo, in vitro and in vivo-gene therapy, risks associated with gene therapy, have been given. One way gene therapy works is to turn viruses into genetic vectors that carry the gene of interest to the target cells. Based on the genome’s nature, these vectors are divided into RNA- based or DNA-based viral vectors. Most RNA-based vectors are derived from simple retroviruses, such as the murine leukaemia virus. One major drawback of these viruses is that they are not transferred to non-dividing cells (post-mitotic cells). This problem can be solved by using new retroviral vectors derived from lentiviruses, such as the human immunodeficiency virus (HIV). DNA-based vectors originate from adeno-viruses and adeno-associated viruses (AAVs). In this report included history, types of gene therapy, vectors & applications.
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  • ISSN: 2349-6002
  • Volume: 10
  • Issue: 9
  • PageNo: 51-56

A Review On: Principle, Types, Methods and Application of Gene Therapy

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