A REVIEW ARTICLE ON THE CHEMICAL STRUCTURE AND MECHANISM OF COLCHICINE

Mr. Bhosale Ganesh Jagannath; Dr. Sachin Subhash Kadam; Mr. Sonawane Pankaj Nandu

A REVIEW ARTICLE ON THE CHEMICAL STRUCTURE AND MECHANISM OF COLCHICINE

Authors: Mr. Bhosale Ganesh Jagannath, Dr. Sachin Subhash Kadam, Mr. Sonawane Pankaj Nandu

Unique Paper ID: 162809
Volume: 10
Issue: 11
PageNo: 1465-1467

Keywords: Colchicine Gout Alkaloids

Abstract:
From ancient times Colchicine has been used for therapeutic purposes and relatively safe anti-inflammatory drug traditionally used in gout and over the last 50 years in familial Mediterranean fever. Colchicine is an alkaloid extracted from the colchicum autumnale plant, having molecular formula C22H25NO6 consisting of three rings. It seems efficacious in the treatment of acute pericarditis and prevention of recurrence, Many researchers are concerned that structural changes will increase their therapeutic effectiveness and reduce toxicity arising from it. In patients suffering from statins and antiplatelet agents following acute coronary syndromes or stable coronary disease, adding low-dose colchicine achieved secondary prevention of major cardiovascular events (myocardial infarction, stroke, or cardiovascular death) with risk reduction up to 0.75. This may also be useful in Behcet's syndrome and most recently, in improving outcomes of COVID-19 infection. The pharmacological effectiveness of colchicine against Gout, Familial Mediterranean Fever, and many other diseases.

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Cite This Article

ISSN: 2349-6002
Volume: 10
Issue: 11
PageNo: 1465-1467

A REVIEW ARTICLE ON THE CHEMICAL STRUCTURE AND MECHANISM OF COLCHICINE

Available:https://ijirt.org/Article?manuscript=162809

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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