A REVIEW ARTICLE ON THE CHEMICAL STRUCTURE AND MECHANISM OF COLCHICINE

A REVIEW ARTICLE ON THE CHEMICAL STRUCTURE AND MECHANISM OF COLCHICINE
Author(s):
Mr. Bhosale Ganesh Jagannath, Dr. Sachin Subhash Kadam, Mr. Sonawane Pankaj Nandu
Keywords:
Colchicine, Gout, Alkaloids
Abstract
From ancient times Colchicine has been used for therapeutic purposes and relatively safe anti-inflammatory drug traditionally used in gout and over the last 50 years in familial Mediterranean fever. Colchicine is an alkaloid extracted from the colchicum autumnale plant, having molecular formula C22H25NO6 consisting of three rings. It seems efficacious in the treatment of acute pericarditis and prevention of recurrence, Many researchers are concerned that structural changes will increase their therapeutic effectiveness and reduce toxicity arising from it. In patients suffering from statins and antiplatelet agents following acute coronary syndromes or stable coronary disease, adding low-dose colchicine achieved secondary prevention of major cardiovascular events (myocardial infarction, stroke, or cardiovascular death) with risk reduction up to 0.75. This may also be useful in Behcet's syndrome and most recently, in improving outcomes of COVID-19 infection. The pharmacological effectiveness of colchicine against Gout, Familial Mediterranean Fever, and many other diseases.
Article Details
Unique Paper ID: 162809 Publication Volume & Issue: Volume 10, Issue 11 Page(s): 1465 - 1467
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