FORMULATION AND EVALUATION OF TRANSDERMAL PATCH FOR ARTHRITIS
Author(s):
Manish Swarnkar, DR. HARISH SHARMA, GYANESH KUMAR SAHU, YOGESH CHANDRA, KHUSHI SHARMA, SURESH KUMAR, DEEPIKA CHANDRA, CHANDRAPRABHA SAHU, RAJESH KUMAR NEMA, PRERANA SAHU
Keywords:
Celecoxib , Transdermal patch and conventional dosage form
Abstract
The formation of Celecoxib Transdermal patch to avoid first pass metabolism and to overcome the problems associated with its biological short half-life and fluctuations in plasma concentration upon oral administration. The patch was prepared using Solvent Casting Method, using HPMC as polymer, Ethanol: distilled water as solvent. The physical evaluation of the prepared patch include Organoleptic observation, moisture uptake, moisture loss, content uniformity test, stability studies, swelling index, folding endurance. The drug release was determined using Franz diffusion cells in phosphate buffer (pH 7.4).
Article Details
Unique Paper ID: 163579

Publication Volume & Issue: Volume 10, Issue 11

Page(s): 1791 - 1796
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