Improving Aceclofenac Solubility through Advanced Crystallization Methods.
Vaishnavi B.Borgaonkar, Amit R. Jaiswal, Shailesh Sharma
Solubility, Aceclofenac, Crystallization, Dissolution.
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with limited water solubility, leading to challenges in its formulation for therapeutic use. In this study, we explored the application of antisolvent crystallization as a method to enhance the solubility of aceclofenac. The antisolvent crystallization technique involves the addition of a non-solvent to the solvent containing the drug, promoting the precipitation of fine crystals with improved solubility properties. Our experiments focused on optimizing the process parameters such as solvent-to-antisolvent ratio, stirring rate, temperature, and concentration of aceclofenac solution. We utilized scanning electron microscopy (SEM) to analyze and characterize the crystal structure, morphology, and thermal properties of the aceclofenac crystals produced. The results demonstrated a significant enhancement in the solubility of aceclofenac through antisolvent crystallization. The optimized conditions yielded fine crystals with increased surface area and improved dissolution rates compared to the untreated drug. These findings suggest the potential of antisolvent crystallization as a promising strategy for enhancing the solubility and bioavailability of poorly soluble drugs like aceclofenac, helping to create pharmaceutical formulations that are more effective.
Article Details
Unique Paper ID: 164091

Publication Volume & Issue: Volume 10, Issue 12

Page(s): 894 - 898
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