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A New Approach For The Synthesis Of Bis(Indolyl) Derivatives And The Evaluation Of Antioxidant And Antiulcer Activity

  • Unique Paper ID: 165106
  • Volume: 11
  • Issue: 1
  • PageNo: 1458-1473
  • Abstract:
  • This study introduces an efficient synthesis method for bis(indolyl) derivatives, highlighting their potential as anti-ulcer and antioxidant agents. The novel approach involves reacting indoles with aldehydes/ ketones in the presence of TBAHS as a catalyst and Ethyl Acetate as a solvent at 95°C for 60-90 minutes. This method offers advantages such as cost efficiency, minimal reagent consumption, one-pot synthesis, and high yield. The synthesized derivatives were characterized using IR to confirm their structures and purity. Subsequent in silico and in vitro experiments assessed their biological activities. The antioxidant activity, evaluated via phosphomolybdate assay, revealed that compounds 1, 2, and 5 exhibit strong antioxidant properties, which may contribute to their anti-ulcer effects by mitigating oxidative stress. The anti-ulcer activity was assessed using an acid neutralizing capacity assay, where compounds 1 and 2 at 50 mg, 1, 2, 3, and 5 at 100 mg, and 2 and 4 at 150 mg demonstrated the highest ANC. These findings suggest that several synthesized compounds could reduce ulcer formation and promote healing, indicating their potential as therapeutic agents.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 1
  • PageNo: 1458-1473

A New Approach For The Synthesis Of Bis(Indolyl) Derivatives And The Evaluation Of Antioxidant And Antiulcer Activity

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