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Formulation and characterization of pioglitazone loaded ethosomal gel

  • Unique Paper ID: 166258
  • Volume: 11
  • Issue: 2
  • PageNo: 2695-2703
  • Abstract:
  • This study aimed to develop and characterize a Pioglitazone-loaded ethosomal gel for enhanced transdermal delivery. Ethosomes, lipid-based vesicles containing high ethanol concentrations, were formulated to encapsulate Pioglitazone, a drug used in diabetes management. The ethosomal gel was prepared using a modified thin-film hydration method, optimizing lipid and ethanol concentrations to achieve stable vesicles with desirable particle size and drug encapsulation efficiency. Characterization studies included evaluating the ethosomal gel's physicochemical properties such as particle size distribution, morphology using scanning electron microscopy (SEM), and drug release kinetics. Stability studies over various storage conditions confirmed the formulation's robustness and shelf-life suitability. Results indicated that the ethosomal gel exhibited uniform spherical vesicles with a mean particle size suitable for effective skin penetration. In vitro release studies demonstrated sustained drug release characteristics, suggesting potential for prolonged therapeutic action. This formulation represents a promising approach to enhance Pioglitazone's bioavailability through transdermal delivery, potentially improving patient compliance and therapeutic outcomes in diabetes treatment. Further research is warranted to explore its clinical efficacy and safety in human trials, paving the way for its application in diabetes management as an innovative drug delivery system.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 2
  • PageNo: 2695-2703

Formulation and characterization of pioglitazone loaded ethosomal gel

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