From Lab to Lungs: Nasal Drug Delivery in Modern Medicine
Author(s):
Smita Nayak, Mohini Bagul, Bhaskar Vaidhun
Keywords:
Nasal spray, Device for drug delivery, Formulation of nasal spray, Nasal anatomy.
Abstract
Nasal delivery has the most appropriate option for topical treatment of local conditions affected the nose and paranasal sinuses, like rhinosinusitis and allergic and non-allergic coryza. Additionally, the nose has considered to be a desirable way of administration for systemic drugs and needle-free vaccinations, specifically when quick absorption and effectiveness have required. Also, the nasal administration may help to address problems including poor bioavailability, slower absorption, drug degradation, and adverse effects in the GI (gastrointestinal) tract by avoiding the liver's first-pass metabolism. intranasal administration has the preferred method of administration for drug delivery to the central nervous system, systemic as well as locally. This article describes the important characteristics of nasal physiology, anatomy, and histology as well as the pharmacological, physicochemical, and biological considerations that need to think carefully while developing a nasal spray formulation. Formulation design and development, characterisation are also discussed in brief. The review also examines the benefits and challenges associated with nasal drug delivery.
Article Details
Unique Paper ID: 166265

Publication Volume & Issue: Volume 11, Issue 2

Page(s): 363 - 368
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