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EVALUATION OF ABROMA AUGUSTA EXTRACT AS ANTI ULCER AGENT

  • Unique Paper ID: 166314
  • Volume: 11
  • Issue: 2
  • PageNo: 648-652
  • Abstract:
  • This study investigates the potential of Abroma augusta root extract in mitigating ethanol-induced gastric ulcers in rats. Ethanol-induced gastric ulcers were induced in rats following a 24-hour fasting period. The animals were treated with Omeprazole (20 mg/kg) or A. augusta root extract at doses of 250 mg/kg and 500 mg/kg orally for 21 days. Parameters such as ulcer index, % inhibition of ulceration, plasma antioxidant levels (superoxide dismutase, catalase, lipid peroxidase), and histopathology were evaluated.The results indicate that the 500 mg/kg dose of A. augusta root extract significantly reduced the ulcer index compared to control groups, demonstrating its efficacy in preventing ethanol-induced gastric lesions. Additionally, this dose maintained elevated levels of plasma antioxidants and preserved the histological integrity of the gastric mucosa, suggesting antioxidant and cytoprotective properties. The presence of tannins, saponins, and alkaloids in the root extract may contribute to these observed effects.In conclusion, the findings support the antiulcer potential of A. augusta root extract, particularly at 500 mg/kg, highlighting its role in protecting against gastric ulcer formation induced by ethanol. These results provide scientific validation for the traditional use of A. augusta in treating gastric ailments and warrant further investigation into its mechanisms of action.This abstract encapsulates the key outcomes of the study, focusing on the efficacy of A. augusta root extract in mitigating ethanol-induced gastric ulcers through its antioxidant and protective properties.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 2
  • PageNo: 648-652

EVALUATION OF ABROMA AUGUSTA EXTRACT AS ANTI ULCER AGENT

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