Formulation And Evaluation Of Paracetamol Tablets Using Fenugreek Seed Mucilage As Natural Disintegrant
Author(s):
P S N Sri Bala, Mohammed Riyaz, Md. Alam Rabbani, Mohammed Shamshoddin, Mohd. Abdul Khadeer, Mohd. Abdul Muheet
Keywords:
Direct Compression, Fenugreek seed mucilage, Flow properties, Paracetamol.
Abstract
Fenugreek, or Trigonella Foenum-graceum in scientific parlance, is a herbaceous plant of the leguminous family that originated in Western Asia. Since it was one of the first plants to be cultivated, it has been extensively utilized for food, food additives, and traditional medicine in every area where it has been planted. Mucilage, a naturally occurring gooey material found in many seed coverings, is present in high concentrations in the seeds. The aim of the current investigation was to separate and examine the fenugreek seed mucilage's suitability as natural disintegrant for creating fast dissolving drug delivery (FDTs) of the chosen model medication, paracetamol. The tablets were prepared using the Direct Compression method using 0.5, 1 and 1.5 % w/w concentrations of fenugreek seed mucilage. Pre-compressional studies were conducted and it was found that the flow properties of all the formulations were within limits. The evaluation test showed that the formulated formulation having 1.0% disintegrants shows the best activity on tablets.
Article Details
Unique Paper ID: 166322

Publication Volume & Issue: Volume 11, Issue 2

Page(s): 430 - 434
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