Formulation And Evaluation Of Paracetamol Tablets Using Fenugreek Seed Mucilage As Natural Disintegrant

  • Unique Paper ID: 166322
  • Volume: 11
  • Issue: 2
  • PageNo: 430-434
  • Abstract:
  • Fenugreek, or Trigonella Foenum-graceum in scientific parlance, is a herbaceous plant of the leguminous family that originated in Western Asia. Since it was one of the first plants to be cultivated, it has been extensively utilized for food, food additives, and traditional medicine in every area where it has been planted. Mucilage, a naturally occurring gooey material found in many seed coverings, is present in high concentrations in the seeds. The aim of the current investigation was to separate and examine the fenugreek seed mucilage's suitability as natural disintegrant for creating fast dissolving drug delivery (FDTs) of the chosen model medication, paracetamol. The tablets were prepared using the Direct Compression method using 0.5, 1 and 1.5 % w/w concentrations of fenugreek seed mucilage. Pre-compressional studies were conducted and it was found that the flow properties of all the formulations were within limits. The evaluation test showed that the formulated formulation having 1.0% disintegrants shows the best activity on tablets.

Copyright & License

Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{166322,
        author = {P S N Sri Bala and Mohammed Riyaz and Md. Alam Rabbani and Mohammed Shamshoddin and Mohd. Abdul Khadeer and Mohd. Abdul Muheet},
        title = {Formulation And Evaluation Of Paracetamol Tablets Using Fenugreek Seed Mucilage As Natural Disintegrant},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {2},
        pages = {430-434},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=166322},
        abstract = {Fenugreek, or Trigonella Foenum-graceum in scientific parlance, is a herbaceous plant of the leguminous family that originated in Western Asia. Since it was one of the first plants to be cultivated, it has been extensively utilized for food, food additives, and traditional medicine in every area where it has been planted. Mucilage, a naturally occurring gooey material found in many seed coverings, is present in high concentrations in the seeds. The aim of the current investigation was to separate and examine the fenugreek seed mucilage's suitability as natural disintegrant for creating fast dissolving drug delivery (FDTs) of the chosen model medication, paracetamol. The tablets were prepared using the Direct Compression method using 0.5, 1 and 1.5 % w/w concentrations of fenugreek seed mucilage. Pre-compressional studies were conducted and it was found that the flow properties of all the formulations were within limits. The evaluation test showed that the formulated formulation having 1.0% disintegrants shows the best activity on tablets.},
        keywords = {Direct Compression, Fenugreek seed mucilage, Flow properties, Paracetamol.},
        month = {July},
        }

Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 2
  • PageNo: 430-434

Formulation And Evaluation Of Paracetamol Tablets Using Fenugreek Seed Mucilage As Natural Disintegrant

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