NEUROINFLAMMATION AND NEURODEGENERATIVE DISEASES

NEUROINFLAMMATION AND NEURODEGENERATIVE DISEASES
Author(s):
LAVANYA YAIDIKAR
Keywords:
Alzheimer's disease; chronic inflammation; interleukin-18; interleukin-1β; NLRP3 inflammasome; neuroinflammation; Parkinson's disease; type 2 diabetes mellitus.
Abstract
Oxidative stress is associated with the onset and progression of various diseases, particularly neurodegenerative conditions. This study reviews the research linking oxidative stress to the pathogenesis of amyotrophic lateral sclerosis (ALS), Parkinson's disease, Alzheimer's disease, and Huntington's disease, focusing on the role of reactive oxygen species. It also examines how oxidative stress influences the inflammatory response. Although oxidative stress and neuroinflammation are distinct clinical phenomena, they are interconnected and impact each other. A thorough understanding of the pathways involved in the initiation and progression of neurodegenerative disorders is essential for developing effective treatments. This paper discusses common antioxidants, both enzymatic and non-enzymatic, as potential therapeutic options for these disorders due to their ability to modulate oxidative stress and mitigate symptoms of neurodegenerative diseases.
Article Details
Unique Paper ID: 166679 Publication Volume & Issue: Volume 11, Issue 2 Page(s): 1546 - 1552
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