A Study of Extracts of Rheum emodi in Experimental Non-Alcoholic Fatty Liver Disease

A Study of Extracts of Rheum emodi in Experimental Non-Alcoholic Fatty Liver Disease
Author(s):
Shraddha Pawar, Dr. Sachin Kumar Jain
Keywords:
NAFLD, Rheum e.modi, paracetamol, hepatotoxicity, hepatoprotective
Abstract
Paracetamol (PCM) is a commonly used analgesic and antipyretic medication, however at large doses, it can cause hepatotoxicity/NAFLD. This study explores the therapeutic potential of Rheum e.modi extracts in treating experimental non-alcoholic fatty liver disease (NAFLD), a liver disorder linked to metabolic syndrome, based on its diverse phytochemical composition against paracetamol-induced damage. This study aims to evaluate the hepatoprotective effects of Rheum e.modi extracts on NAFLD in an experimental model, conduct histopathological examination of liver tissues, investigate the potential of Rheum e.modi extracts in modulating metabolic pathways related to lipid metabolism, insulin sensitivity, and glucose homeostasis, and establish a dose-response relationship to determine the optimal dosage for significant therapeutic effects while ensuring safety.
Article Details
Unique Paper ID: 167204 Publication Volume & Issue: Volume 11, Issue 3 Page(s): 576 - 583
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