formulation and evaluation of nanosuspension loaded topical gel

formulation and evaluation of nanosuspension loaded topical gel
Author(s):
safiya bee, sakshi Aole, vikas jain
Keywords:
Etodolac, Non-steroidal anti-inflammatory drugs, Arthritis, Pearl milling technique, Ultra violet spectroscopy.
Abstract
This study aims to prepare a topical formulation of etodolac. Presently, a total of 5 formulations were formulated, for which 2 steps were followed. First the preparation of nanosuspension by using pearl milling technique, and the second one incorporates them into a gel formulation by adding a gelling agent carbopol 940. Nanosuspension was prepared to improve the poor solubility of the drug or to enhance the bioavailability of drug, and to improve the drug penetration into the skin. In this paper, a comparative study is illustrated between the etodolac nanosuspension-loaded gel and pure etodolac gel. In the formulation of nanosuspension different concentrations of poloxamer 407 and different speeds of stirrer were used. The formulation was evaluated for pH, clarity, spreadability, drug content, etc. The in vitro diffusion studies showed satisfactory results. On the basis of evaluation parameters, F3 and F4 showed a good release profile as well as also showed an ideal characteristic for gel formulation.
Article Details
Unique Paper ID: 167211 Publication Volume & Issue: Volume 10, Issue 7 Page(s): 562 - 569
Article Preview & Download

Share This Article

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024

Last Date: 15th March 2024

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on [email protected]