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TRABECTEDIN : A MARINE MAGIC IN ONCOLOGY

  • Unique Paper ID: 168456
  • Volume: 11
  • Issue: 5
  • PageNo: 1385-1396
  • Abstract:
  • A powerful anti-tumor medication derived from marine sources, trabectedin (Yondelis®) exhibits high activity against a variety of soft tissue sarcomas (STS). Its distinct mode of action and clinical success in treating specific cancers have made it a noteworthy treatment alternative in oncology. It is used to treat ovarian cancer that has synergistic actionin combination with other medications. In order to disrupt the transcriptional machinery of cancer cells and cause cell cycle arrest and apoptosis, trabectedin binds to the minor groove of DNA. It also alters the production of cytokines and tumor-associated macrophages, which modifies the tumour microenvironment and provides a multimodel approach to cancer treatment. Studies conducted both in vitro and in vivo showed that trabectedin, when coupled with other antitumor drugs like cisplatin, doxorubicin, or irinotecan, had an additive or synergistic impact. Thorough examination of the pharmacological characteristics, mechanisms of action, clinical uses, and current research of trabectedin is provided by this review.The pharmacokinetic and safety properties of trabectedin are reviewed in this article. Electronic databases (such as PubMed and Drug bank) were used to find records based on predetermined search criteria. We also emphasise trabectedin's growing importance in oncology by examining ongoing research into its potential in other cancer types and its use in combination therapy. An insight on possible developments and future paths for the use of trabectedin in oncology rounds up this assessment. Trabectedin is an intriguing illustration of how marine biology can help create cutting-edge cancer treatments, providing patients with difficult-to-treat cancers with hope.
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  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 5
  • PageNo: 1385-1396

TRABECTEDIN : A MARINE MAGIC IN ONCOLOGY

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