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Interaction of Naringenin with Ryanodine receptor in Human and Caenorhabditis elegans

  • Unique Paper ID: 169334
  • Volume: 9
  • Issue: 8
  • PageNo: 936-940
  • Abstract:
  • Calcium channels present on membrane and sarcoplasmic reticulum modulate the cytoplasmic calcium level which act as a secondary messenger thus regulate various activity of cell. Naringenin (Nar), a natural flavonoid present in citrus and grape fruits known for its antioxidant, cardiovascular effects. In this study, we are trying to elucidate the impact of binding of Nar on Ryanodine receptor (RyR) which is a principal channel for calcium release from sarcoplasmic reticulum in human (RyR2) as well as in Caenorhabditis elegans (ryr-1) along with its effect on its muscle health. To study the docking of Nar with RyR receptor in C. elegans we prepared homolog model via alpha fold2 server of ryr-1 receptor for C. elegans because of the absence of their X ray crystal structure. In this study, we observed that the Nar show the interaction with N-terminal domain (NTD) of RyR2 (4JKQ) and handle domain of ryr-1. Naringenin binding with these calcium channels might be helpful in controlling the dysregulation of calcium release from ryanodine receptor.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 9
  • Issue: 8
  • PageNo: 936-940

Interaction of Naringenin with Ryanodine receptor in Human and Caenorhabditis elegans

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